Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?
نویسندگان
چکیده
منابع مشابه
S16-04 Transcription factor network governing pluripotency
Like in many animal systems, plant stem cells reside in niches and are maintained by short-range signals emanating from organizing centres. The Arabidopsis PLETHORA genes encode transcription factors required for root stem cell specification. PLT expression is induced by the indolic hormone auxin, depends on auxin response factors and follows auxin accumulation patterns. The PLT gene clade exte...
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Stem cells are defined by the simultaneous possession of the seemingly incongruent properties of self-renewal and multi-lineage differentiation potential. To maintain a stem cell population, these opposing forces must be balanced. Transcription factors that function to direct pluripotent cell identity are not all equally distributed throughout the pluripotent cell population. While Oct4 levels ...
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S omatic cells derived from differentiated tissues can be reprogrammed back to a pluripotent state. However, multiple barriers exist to prevent such extreme dedifferentiation from occurring in vivo, which explains the inefficient induction of pluripotency by ectopic coexpression of Oct4, Sox2, Klf4, and c-Myc (OSKM) in somatic cells. In PNAS, Ganier et al. (1) report a method that uses frog egg...
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Objective- In the present study we investigated the isolation protocol, population doubling time (PDT) and the expression of a pluripotential gene by RT-PCR analysis of early transcription factor Nanog in caprine umbilical cord (CUC) Wharton's jelly mesenchymal cells (WJMCs). Design- Experimental in vitro study. Animals- Four mix breed goat. Procedures- CUCs were collected from abattoi...
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The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In additio...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2012
ISSN: 0959-437X
DOI: 10.1016/j.gde.2012.07.003